Investigation of Systolic and Diastolic deviations in the obese: a cardiovascular magnetic resonance imaging and metabolic technique.
Obesity is one of the major health issues in developed Western countries, especially in the United States of America (Danias, 2003). Previous investigations with magnetic resonance imaging have shown that obesity independently alters the structure and systolic/diastolic function of the heart. This has been evaluated with great detail by using cardiovascular magnetic resonance imaging (CMR). CMR can observe the left and right ventricular volumes and cardiac output of the heart without invasive imaging modalities. This technology and technique has been able to show how the mass of the heart has increased and the systolic/diastolic output volumes have decreased in obese patients. At this time, there has not been a study on the rate at which the mass of the heart and the systolic/diastolic functions deviate from a healthy (lean) patient towards obesity. I plan on using cardiovascular magnetic resonance imaging to examine the rate of increased mass and deviations from healthy systolic/diastolic functions towards a state of obesity.
Laboratory rats (Rattus norvegicus) provide a unique opportunity for manipulation and observation of a cardiovascular system that is extremely similar to the human cardiovascular system. They allow for specific questions to be analyzed that could provide insight into human cardiac health. By simulating a lifestyle conducive to development to an obese state, cardiovascular magnetic resonance imaging can record the deviations of the lab rat’s heart function and structure over time. This provides a unique opportunity to observe (with great detail from CMR) the rate at which mass is added to the heart, and also, when the left and right ventricles begin to have unhealthy deviations in their output volumes. This insight would provide crucial information for understanding the rate towards obesity at...
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